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Representations of the Aryl Hydrocarbon Receptor.  From Szöllősi et al. 2016 and Tagliabue et al. 2019.

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The Aryl Hydrocarbon Receptor

Healthy microbiota on the skin and in the colon produce naturally-occurring aryl hydrocarbon receptor (AhR) agonists that play an important role in keeping our immune system in balance. AhR activation has been associated with decreased T-helper 17 activity and increased T-regulatory cell differentiation, regulation of inflammatory cytokines, and increased barrier function. Several inflammatory diseases such as inflammatory bowel disease, psoriasis, and hidradenitis suppurativa have been associated with defects in AhR signaling. Azora’s small molecule formulations are designed to locally activate the AhR in the skin and in the colon to rebalance the body’s natural immune response mechanisms in order to treat serious inflammatory diseases. 

Key Publications